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TopCoW 2024

Time-of-flight MR angiography (fixed) and CT angiography (moving) of the head of one patient of a stroke centre, with the arteries of the circle of Willis labelled on both (TopCoW 2024 training set).

10 test pairsbrainsame patientfixed MR, moving CTaligned once by the benchmarkresearch only
Read before comparing (10)
  • Truth. Two doctoral researchers trained by a senior neurosurgeon labelled the vessels in virtual reality, each on half of the patients, viewing both images, uncertain cases going to the neurosurgeon or a panel; after the first 260 images a network pre-labelled and people corrected. On five patients the annotators agree at a Dice of about 0.90 a class, 0.76 to 0.89 for the communicating arteries and the third A2.
  • Label ends. Arteries leaving the circle are labelled up to their first major bifurcation, so where a label ends is a judgement on each image.
  • Carotids. The internal carotids are labelled along their whole course on the MRA but only from C7 on the CTA, the MRA's holding 3 to 4 times the volume on the first 13 cases built. No field can make those extents equal, so they form a separate label set (dice_ica, hd95_ica), shown, never ranked; the board ranks the other eleven classes.
  • Small vessels. The arteries are 1 to 4 mm wide, so a one-millimetre shift halves a small artery's overlap. The communicating arteries and the third A2 hold a few tens of mm³ and are often on one image only: only the classes both maps hold are scored, 7 to 10 a test pair.
  • Alignment. The scans come from separate scanners, frame origins up to about 1.5 m apart, both cropped to the braincase. The moving header carries one rigid start from the intensities and body masks, no vessel label used, turning the CTA by 9.58 to 38.67 degrees; a translation alone left gross rotation (Dice 0.014, HD95 8.21 mm).
  • Baseline. After the start the ten test pairs score a median Dice of 0.614 (0.498 to 0.745) and an HD95 of 1.61 mm (0.97 to 3.28); the carotid set 0.348 and 10.14 mm.
  • Images. Each keeps its native grid: the MRA, 3D time of flight mostly at 3 T, about 0.3 mm in plane and 0.6 mm slices; the CTA, in Hounsfield units, 0.37 to 0.59 mm and 0.625 to 0.75 mm. The two are separate examinations, how far apart the paper does not say.
  • Cohort. Patients of the University Hospital Zurich's Stroke Center in 2018 and 2019 with a suspected stroke, median age 74, without a large aneurysm in the circle or a rare variant the 13 classes cannot describe.
  • Overlap. TopBrain labels more vessels on 25 of these patients: the five here (008 in test; 001, 002, 003 and 014 in development) stay, and TopBrain holds the 20 others, which a larger draw here must avoid.
  • Outside numbers. None: the challenge ranks segmentation, not registration.
AccuracySmoothnessCost
#MethodDiceChangeHD95 mmSDlogJFolds %Time sRAM GBGPU GBImages
11–2ConvexAdam (MIND)GPUapp0.730 ±0.028+0.1181.74 ±0.490.1312.04385.113.1
21–2NiftyRegCPUapp0.746 ±0.028+0.1352.06 ±0.840.4263.242034.4
No registration0.612 ±0.0501.73 ±0.460.0000.00

The order averages each method's ranks on Dice, HD95 mm, SDlogJ, so the first one is not always the best in every column. ± is the 95% interval of the mean over the 10 pairs. Two neighbours are tied when a paired Wilcoxon test on the shared pairs does not find the upper one better on Dice (5%): the places a method could hold are then shown under its own. The best value of each column is in colour. Click a row to see its images, a column title to sort by it. Time and memory measured on Laptop.

Dice: how much the organ contours overlap, 1 is perfect. HD95: distance between the contours' surfaces. SDlogJ: how irregular the deformation is, 0 is perfectly smooth. Folds: share of the image where the deformation folds over itself.

Pair by pair

Click a score to look at that result: the fixed image, and over it the moving image after registration, with the annotations. Underlined scores have their image; for the others you see the pair without the result. A green cell gained against no registration on that pair, a red one lost.

About the data

Test pairs
10 test patients drawn with seed 2026 among the 105 eligible, then 10 different development patients. The 20 patients TopBrain holds are left out of the pool.
Truth
contours by experts ica by experts the dataset's voxel labels of the circle of Willis on each image, without the internal carotid arteries: basilar artery, posterior, middle and anterior cerebral arteries, posterior and anterior communicating arteries, and a third A2 where there is one (11 classes)
Licence
opendata.swiss 'Open use. Must provide the source. Use for commercial purposes requires permission of the data owner.'
10 pairs for tuning, never tested

topcow_001, topcow_002, topcow_003, topcow_139, topcow_051, topcow_009, topcow_014, topcow_163, topcow_031, topcow_140